Prometheus Biosciences

remote
26 - 50 Employees
< 10 Engineers
$100M+ Funding
Exited (IPO)

The first company using precision medicine and companion diagnostics to create new therapeutics for GI and immune-mediated diseases.

Prometheus Biosciences photo 1 Prometheus Biosciences photo 2 Prometheus Biosciences photo 3

Why join us?

  • Proprietary access to world's largest gastrointestinal bioinformatics databases, and collaborations with leading experts in genomics and immunology, enables you to make a difference for patients using your technical skills.

  • Well-capitalized with recent successful IPO; over $450MM raised. We pay real salaries and provide fantastic benefits.

  • As a member of our Data Science and Engineering team, your work will be central to our vision of enabling precision medicine for new disease areas.


Engineering at Prometheus Biosciences

Engineering team and processes

Our team operates on 1-2 week sprints that begin with a planning meeting that ends in defined tasks with specific owners, acceptance criteria, and estimated time to completion.

Halfway through the sprint, we refine our backlog.

Sprints end with a Friday afternoon retro, where we share what went well, what can be improved, and action items for the team.

Code lives on GitHub. We do code reviews before PRs are merged. We'd like to set up automated CI/CD where appropriate.

We are still determining project management tools for agile. Currently the debate is Notion vs GitHub.

We currently do standup twice a week, but are thinking of moving to a Tuesday AM planning meeting with daily asynchronous checkins via Slack.

Technical Challenges

We're ingesting, standardizing, and version-controlling multimodal biomedical data, including gene sequence, protein expression, histopathology (images of tissue slices), tabular electronic medical record data, and more.

Labels defining a clinical phenotype (e.g. did the patient respond well to therapy?) change over time and vary depending on the definition applied, so we must develop a lightweight and programmatic way of defining labels for supervised learning.

We need to performantly query and visualize these data, and serve applications to non-techncial R&D scientists so they can do the same and become more proficient with modern data science tools.

We also will build a suite of ML/DL tools for power users .

Tech stack
Google Cloud Platform
Unix shell
Python
Anaconda
R
Bash
PyTorch
TensorFlow
xgboost
Pandas
Seaborn
SQL
PostgreSQL
sklearn

Working at Prometheus Biosciences

Many of us have families. We usually leave work around 5-6 PM. We enjoy our weekends and imagine you feel the same way. However, as a rapidly growing company with big goals, we are really motivated to work hard and make a difference for patients.

Occasionally some of us stay late, or work on a Saturday. But this is always self-driven, rather than an unwritten expectation of the company.

We care about results, not sheer hours of effort. This is especially important for engineers and data scientists. We want Prometheus to be a place where you will do the best work of your career.

Our company values help align our culture. They are: - Focus on the individual patient.
- Be bold - no guts, no glory.
- Follow the science and the data.
- Engage in rigorous, honest debate.
- Let passion fuel progress.
- Be accountable to each other.
- Evolve continuously.
- Embrace moonshot thinking.

Diversity and Inclusion
Connect with our team during your hiring process

As part of our commitment to an inclusive workplace, we are happy to offer prospective engineers the chance to connect with our engineering employees who come from underrepresented backgrounds. It’s a way to get a better sense of our team and what it might be like to work with us.

If you’re interested in connecting with our team, be sure to bring this up during one of our introductory calls!

Perks & benefits
  • Beautiful Office

    Later this year we will move to a brand new office with lots of glass, steel, and outdoor spaces by Torrey Pines in San Diego, CA. We will be near several other major biotech companies.

  • Company Retreats
  • Flexible Hours
  • Work from Home

    Remote first

  • Health Insurance
  • Team Activities
  • 401(k) Contribution
  • Free Food

    Snacks and beverages in office.

  • Gym/Fitness

    Our office later this will will have an on-site fitness center.

  • Transportation

    If you are remote and visit HQ in San Diego, we pay for travel and lodging.

  • Social impact driven

    We develop new therapeutics and companion diagnostics for a medically underserved population.

  • Dedicated Human Resources team

    Our new Chief People Officer is building our our HR function.

  • Workshops/Conferences

    We encourage participation in workshops and conferences, and will arrange to support engineers who want to develop additional professional skills.

  • Other

    New MacBook Pro and equipment stipend for monitor, keyboard, mouse, noise-canceling headphones, etc.

  • Prioritizes diversity in hiring
  • Travel

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